Paper List
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SpikGPT: A High-Accuracy and Interpretable Spiking Attention Framework for Single-Cell Annotation
This paper addresses the core challenge of robust single-cell annotation across heterogeneous datasets with batch effects and the critical need to ide...
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Unlocking hidden biomolecular conformational landscapes in diffusion models at inference time
This paper addresses the core challenge of efficiently and accurately sampling the conformational landscape of biomolecules from diffusion-based struc...
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Personalized optimization of pediatric HD-tDCS for dose consistency and target engagement
This paper addresses the critical limitation of one-size-fits-all HD-tDCS protocols in pediatric populations by developing a personalized optimization...
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Realistic Transition Paths for Large Biomolecular Systems: A Langevin Bridge Approach
This paper addresses the core challenge of generating physically realistic and computationally efficient transition paths between distinct protein con...
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Consistent Synthetic Sequences Unlock Structural Diversity in Fully Atomistic De Novo Protein Design
This paper addresses the core pain point of low sequence-structure alignment in existing synthetic datasets (e.g., AFDB), which severely limits the pe...
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MoRSAIK: Sequence Motif Reactor Simulation, Analysis and Inference Kit in Python
This work addresses the computational bottleneck in simulating prebiotic RNA reactor dynamics by developing a Python package that tracks sequence moti...
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On the Approximation of Phylogenetic Distance Functions by Artificial Neural Networks
This paper addresses the core challenge of developing computationally efficient and scalable neural network architectures that can learn accurate phyl...
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EcoCast: A Spatio-Temporal Model for Continual Biodiversity and Climate Risk Forecasting
This paper addresses the critical bottleneck in conservation: the lack of timely, high-resolution, near-term forecasts of species distribution shifts ...
Vessel Network Topology in Molecular Communication: Insights from Experiments and Theory
Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
30秒速读
IN SHORT: This work addresses the critical lack of experimentally validated channel models for molecular communication within complex vessel networks, which is a prerequisite for designing reliable biomedical applications.
核心创新
- Methodology Proposes a novel, comprehensive channel model for molecular communication in vessel networks, incorporating advection, molecular/turbulent diffusion, and adsorption/desorption at vessel walls.
- Methodology Introduces two novel metrics—molecule delay and multi-path spread—to quantify the impact of vessel network topology on signal dispersion and the resulting signal-to-noise ratio (SNR).
- Methodology Provides the first end-to-end experimental validation of a molecular communication model in branched vessel network topologies using a dedicated SPION (superparamagnetic iron-oxide nanoparticle) testbed.
主要结论
- The proposed channel model, validated against experimental data from branched topologies, accurately captures key transport dynamics (advection, diffusion, sorption) in vessel networks.
- The introduced metrics (molecule delay, multi-path spread) successfully establish a quantifiable link between vessel network structure and the resulting signal-to-noise ratio (SNR) at the receiver.
- The framework enables practical applications such as optimizing sensor placement in the cardiovascular system under specific SNR constraints and guiding the design of experimental testbeds.
摘要: The notion of synthetic molecular communication (MC) refers to the transmission of information via signaling molecules and is foreseen to enable innovative medical applications in the human cardiovascular system (CVS). Crucially, the design of such applications requires accurate and experimentally validated channel models that characterize the propagation of signaling molecules, not just in individual blood vessels, but in complex vessel networks, as prevalent in the CVS. However, experimentally validated models for MC in VNs remain scarce. To address this gap, we propose a novel channel model for MC in complex VN topologies, which captures molecular transport via advection, molecular and turbulent diffusion, as well as adsorption and desorption at the vessel walls. We specialize this model for superparamagnetic iron-oxide nanoparticles as signaling molecules by introducing a new receiver (RX) model for planar coil inductive sensors, enabling end-to-end experimental validation with a dedicated SPION testbed. Validation covers a range of channel topologies, from single-vessel topologies to branched VNs with multiple paths between transmitter (TX) and RX. Additionally, to quantify how the VN topology impacts signal quality, and inspired by multi-path propagation models in conventional wireless communications, we introduce two metrics, namely molecule delay and multi-path spread. We show that these metrics link the VN structure to molecule dispersion induced by the VN and mediately to the resulting signal-to-noise ratio (SNR) at the RX. The proposed VN structure-SNR link is validated experimentally, demonstrating that the proposed framework can support tasks such as optimal sensor placement in the CVS or the identification of suitable testbed topologies for specific SNR requirements. All experimental data are openly available on Zenodo.