Paper List
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STAR-GO: Improving Protein Function Prediction by Learning to Hierarchically Integrate Ontology-Informed Semantic Embeddings
This paper addresses the core challenge of generalizing protein function prediction to unseen or newly introduced Gene Ontology (GO) terms by overcomi...
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Incorporating indel channels into average-case analysis of seed-chain-extend
This paper addresses the core pain point of bridging the theoretical gap for the widely used seed-chain-extend heuristic by providing the first rigoro...
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Competition, stability, and functionality in excitatory-inhibitory neural circuits
This paper addresses the core challenge of extending interpretable energy-based frameworks to biologically realistic asymmetric neural networks, where...
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Enhancing Clinical Note Generation with ICD-10, Clinical Ontology Knowledge Graphs, and Chain-of-Thought Prompting Using GPT-4
This paper addresses the core challenge of generating accurate and clinically relevant patient notes from sparse inputs (ICD codes and basic demograph...
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Learning From Limited Data and Feedback for Cell Culture Process Monitoring: A Comparative Study
This paper addresses the core challenge of developing accurate real-time bioprocess monitoring soft sensors under severe data constraints: limited his...
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Cell-cell communication inference and analysis: biological mechanisms, computational approaches, and future opportunities
This review addresses the critical need for a systematic framework to navigate the rapidly expanding landscape of computational methods for inferring ...
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Generating a Contact Matrix for Aged Care Settings in Australia: an agent-based model study
This study addresses the critical gap in understanding heterogeneous contact patterns within aged care facilities, where existing population-level con...
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Emergent Spatiotemporal Dynamics in Large-Scale Brain Networks with Next Generation Neural Mass Models
This work addresses the core challenge of understanding how complex, brain-wide spatiotemporal patterns emerge from the interaction of biophysically d...
可变食性范围模型中向泛化主义的缓慢演化
Department of Mathematical Sciences, University of Bath, Claverton Down, Bath, BA2 7AY, United Kingdom
30秒速读
IN SHORT: 通过证明是种群统计噪声（而非确定性动力学）驱动了模式形成和泛化食性的演化，解决了间接竞争下物种形成的悖论。
核心创新
- Methodology Develops a continuous-space resource-consumer model with explicit resource dynamics and evolvable dietary range, extending beyond fixed-preference Lotka-Volterra frameworks.
- Theory Demonstrates that deterministic analysis predicts homogeneous steady states (no species), but stochastic simulations with demographic noise induce persistent pattern formation interpreted as species.
- Methodology Uses Fourier analysis of linearized dynamics to predict the dominant perturbation modes (e.g., number of species) from the power spectrum, linking analytical predictions to simulation outcomes.
主要结论
- 对于固定食性范围（w=0.2），傅里叶分析预测在 kL/2π=5 处存在主导模式，这对应于在随机模拟中观察到的5个等间距物种的形成（图2，3A）。
- 在可演化食性范围模型中，动力学发生在两个时间尺度上：快速协同演化到准稳态流形，随后缓慢弛豫向均匀态。种群统计噪声阻止了这种弛豫，维持了模式。
- 泛化食性（宽w）在长时间尺度上随机演化，因为与由相同资源生产率支持的、种群规模较小的专化集群相比，它们更不易受到灭绝风险的影响。
摘要: 共享栖息地的物种会协同演化以利用可用资源，因为消费受到消费者与资源之间竞争和负反馈回路的调节。给定物种的食性范围决定了其可获取的资源，从而决定了与之竞争的其他物种。狭窄的食性范围以过度依赖少量资源为代价避免竞争；相反，广泛的食性范围提供了更多替代选择，但也增加了与其他物种竞争的机会。在此，我们研究了生态位形成数学模型中食性范围的演化。我们发现了高度路径依赖的协同演化动力学，其特征是长寿命的准稳态。最终，随机效应驱动了泛化食性的演化，正如我们在分析和模拟中所揭示的。