Paper List
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EnzyCLIP: A Cross-Attention Dual Encoder Framework with Contrastive Learning for Predicting Enzyme Kinetic Constants
This paper addresses the core challenge of jointly predicting enzyme kinetic parameters (Kcat and Km) by modeling dynamic enzyme-substrate interaction...
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Tissue stress measurements with Bayesian Inversion Stress Microscopy
This paper addresses the core challenge of measuring absolute, tissue-scale mechanical stress without making assumptions about tissue rheology, which ...
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DeepFRI Demystified: Interpretability vs. Accuracy in AI Protein Function Prediction
This study addresses the critical gap between high predictive accuracy and biological interpretability in DeepFRI, revealing that the model often prio...
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Hierarchical Molecular Language Models (HMLMs)
This paper addresses the core challenge of accurately modeling context-dependent signaling, pathway cross-talk, and temporal dynamics across multiple ...
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Stability analysis of action potential generation using Markov models of voltage‑gated sodium channel isoforms
This work addresses the challenge of systematically characterizing how the high-dimensional parameter space of Markov models for different sodium chan...
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Personalized optimization of pediatric HD-tDCS for dose consistency and target engagement
This paper addresses the critical limitation of one-size-fits-all HD-tDCS protocols in pediatric populations by developing a personalized optimization...
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Consistent Synthetic Sequences Unlock Structural Diversity in Fully Atomistic De Novo Protein Design
This paper addresses the core pain point of low sequence-structure alignment in existing synthetic datasets (e.g., AFDB), which severely limits the pe...
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Generative design and validation of therapeutic peptides for glioblastoma based on a potential target ATP5A
This paper addresses the critical bottleneck in therapeutic peptide design: how to efficiently optimize lead peptides with geometric constraints while...
Emergent Bayesian Behaviour and Optimal Cue Combination in LLMs
Huawei Noah’s Ark Lab, London, UK | AI Centre, Department of Computer Science, University College London, London, UK
The 30-Second View
IN SHORT: This paper addresses the critical gap in understanding whether LLMs spontaneously develop human-like Bayesian strategies for processing uncertain information, revealing that high accuracy does not guarantee robust multimodal integration.
Innovation (TL;DR)
- Methodology Introduces BayesBench, the first psychophysics-inspired behavioral benchmark for LLMs with four magnitude estimation tasks (length, location, distance, duration) across text and image modalities.
- Methodology Develops Bayesian Consistency Score (BCS) to detect Bayes-consistent behavioral shifts even when accuracy saturates, enabling separation of capability from computational strategy.
- Biology Demonstrates emergent Bayesian behavior in capable LLMs without explicit training, with Llama-4 Maverick showing cue-combination efficiency exceeding human biological systems (RRE > 1 against Bayesian oracle).
Key conclusions
- GPT-5 Mini achieves perfect text accuracy (NRMSE ≈ 0) but fails to integrate visual cues efficiently, showing poor cue-combination efficiency (RRE < 1) despite high capability.
- Llama-4 Maverick demonstrates emergent Bayesian behavior with cue-combination efficiency exceeding Bayesian reliability-weighted baselines (RRE > 1), suggesting non-linear integration strategies.
- Bayesian Consistency Score reveals that more accurate models show stronger evidence of Bayesian behavior, with BCS positively correlated with accuracy across nine evaluated LLMs.
Abstract: Large language models (LLMs) excel at explicit reasoning, but their implicit computational strategies remain underexplored. Decades of psychophysics research show that humans intuitively process and integrate noisy signals using near-optimal Bayesian strategies in perceptual tasks. We ask whether LLMs exhibit similar behaviour and perform optimal multimodal integration without explicit training or instruction. Adopting the psychophysics paradigm, we infer computational principles of LLMs from systematic behavioural studies. We introduce a behavioural benchmark - BayesBench: four magnitude estimation tasks (length, location, distance, and duration) over text and image, inspired by classic psychophysics, and evaluate a diverse set of nine LLMs alongside human judgments for calibration. Through controlled ablations of noise, context, and instruction prompts, we measure performance, behaviour and efficiency in multimodal cue-combination. Beyond accuracy and efficiency metrics, we introduce a Bayesian Consistency Score that detects Bayes-consistent behavioural shifts even when accuracy saturates. Our results show that while capable models often adapt in Bayes-consistent ways, accuracy does not guarantee robustness. Notably, GPT-5 Mini achieves perfect text accuracy but fails to integrate visual cues efficiently. This reveals a critical dissociation between capability and strategy, suggesting accuracy-centric benchmarks may over-index on performance while missing brittle uncertainty handling. These findings reveal emergent principled handling of uncertainty and highlight the correlation between accuracy and Bayesian tendencies. We release our psychophysics benchmark and consistency metric as evaluation tools and to inform future multimodal architecture designs111Project webpage: https://bayes-bench.github.io.