Paper List
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EnzyCLIP: A Cross-Attention Dual Encoder Framework with Contrastive Learning for Predicting Enzyme Kinetic Constants
This paper addresses the core challenge of jointly predicting enzyme kinetic parameters (Kcat and Km) by modeling dynamic enzyme-substrate interaction...
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Tissue stress measurements with Bayesian Inversion Stress Microscopy
This paper addresses the core challenge of measuring absolute, tissue-scale mechanical stress without making assumptions about tissue rheology, which ...
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DeepFRI Demystified: Interpretability vs. Accuracy in AI Protein Function Prediction
This study addresses the critical gap between high predictive accuracy and biological interpretability in DeepFRI, revealing that the model often prio...
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Hierarchical Molecular Language Models (HMLMs)
This paper addresses the core challenge of accurately modeling context-dependent signaling, pathway cross-talk, and temporal dynamics across multiple ...
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Stability analysis of action potential generation using Markov models of voltage‑gated sodium channel isoforms
This work addresses the challenge of systematically characterizing how the high-dimensional parameter space of Markov models for different sodium chan...
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Personalized optimization of pediatric HD-tDCS for dose consistency and target engagement
This paper addresses the critical limitation of one-size-fits-all HD-tDCS protocols in pediatric populations by developing a personalized optimization...
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Consistent Synthetic Sequences Unlock Structural Diversity in Fully Atomistic De Novo Protein Design
This paper addresses the core pain point of low sequence-structure alignment in existing synthetic datasets (e.g., AFDB), which severely limits the pe...
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Generative design and validation of therapeutic peptides for glioblastoma based on a potential target ATP5A
This paper addresses the critical bottleneck in therapeutic peptide design: how to efficiently optimize lead peptides with geometric constraints while...
EcoCast: A Spatio-Temporal Model for Continual Biodiversity and Climate Risk Forecasting
Concordia University | Algoma University
The 30-Second View
IN SHORT: This paper addresses the critical bottleneck in conservation: the lack of timely, high-resolution, near-term forecasts of species distribution shifts under rapidly changing environmental conditions, moving beyond static models to operational, data-driven decision support.
Innovation (TL;DR)
- Methodology First transformer-based model applied to ecological and climate risk forecasting in Africa, using sequence-to-point prediction (12-month environmental sequences → next-month species occurrence) with explicit temporal dependency modeling via self-attention.
- Methodology Integration of continual learning (rehearsal + EWC) into biodiversity forecasting, enabling model updates with new data streams without catastrophic forgetting, crucial for non-stationary climate impacts.
- Biology Operational near-term forecasting paradigm (monthly to seasonal) that requires no future climate projections, using observed environmental sequences to predict immediate conservation-relevant shifts, bridging geophysical forecasting architectures with species distribution modeling.
Key conclusions
- EcoCast achieves macro-averaged F1 score of 0.65 and PR-AUC of 0.72 on 2023 holdout data for five African bird species, representing +34 and +43 percentage point improvements respectively over Random Forest baseline (F1=0.31, PR-AUC=0.29).
- Transformer architecture successfully captures critical temporal dependencies: annual seasonality via positional encoding, lagged environmental responses (2-4 month delays), and cross-species ecological signals through joint multi-label training.
- The framework demonstrates operational feasibility with monthly forecast updates using near-real-time data (ERA5 available within 5 days, final data 2-3 months later), enabling alignment with conservation planning cycles rather than static decadal projections.
Abstract: Increasing climate change and habitat loss are driving unprecedented shifts in species distributions. Conservation professionals urgently need timely, high-resolution predictions of biodiversity risks, especially in ecologically diverse regions like Africa. We propose EcoCast, a spatio-temporal model designed for continual biodiversity and climate risk forecasting. Utilizing multisource satellite imagery, climate data, and citizen science occurrence records, EcoCast predicts near-term (monthly to seasonal) shifts in species distributions through sequence-based transformers that model spatio-temporal environmental dependencies. The architecture is designed with support for continual learning to enable future operational deployment with new data streams. Our pilot study in Africa shows promising improvements in forecasting distributions of selected bird species compared to a Random Forest baseline, highlighting EcoCast's potential to inform targeted conservation policies. By demonstrating an end-to-end pipeline from multi-modal data ingestion to operational forecasting, EcoCast bridges the gap between cutting-edge machine learning and biodiversity management, ultimately guiding data-driven strategies for climate resilience and ecosystem conservation throughout Africa.