Paper List
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A Unified Variational Principle for Branching Transport Networks: Wave Impedance, Viscous Flow, and Tissue Metabolism
This paper solves the core problem of predicting the empirically observed branching exponent (α≈2.7) in mammalian arterial trees, which neither Murray...
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Household Bubbling Strategies for Epidemic Control and Social Connectivity
This paper addresses the core challenge of designing household merging (social bubble) strategies that effectively control epidemic risk while maximiz...
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Empowering Chemical Structures with Biological Insights for Scalable Phenotypic Virtual Screening
This paper addresses the core challenge of bridging the gap between scalable chemical structure screening and biologically informative but resource-in...
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A mechanical bifurcation constrains the evolution of cell sheet folding in the family Volvocaceae
This paper addresses the core problem of why there is an evolutionary gap in species with intermediate cell numbers (e.g., 256 cells) in Volvocaceae, ...
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Bayesian Inference in Epidemic Modelling: A Beginner’s Guide Illustrated with the SIR Model
This guide addresses the core challenge of estimating uncertain epidemiological parameters (like transmission and recovery rates) from noisy, real-wor...
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Geometric framework for biological evolution
This paper addresses the fundamental challenge of developing a coordinate-independent, geometric description of evolutionary dynamics that bridges gen...
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A multiscale discrete-to-continuum framework for structured population models
This paper addresses the core challenge of systematically deriving uniformly valid continuum approximations from discrete structured population models...
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Whole slide and microscopy image analysis with QuPath and OMERO
使QuPath能够直接分析存储在OMERO服务器中的图像而无需下载整个数据集,克服了大规模研究的本地存储限制。
D-MEM: Dopamine-Gated Agentic Memory via Reward Prediction Error Routing
UC San Diego | Carnegie Mellon University
30秒速读
IN SHORT: This paper addresses the fundamental scalability bottleneck in LLM agentic memory systems: the O(N²) computational complexity and unbounded API token costs caused by processing every user utterance through expensive memory evolution pipelines, regardless of information value.
核心创新
- Methodology Introduces D-MEM, a bio-inspired architecture implementing dopamine-gated fast/slow routing based on Agentic Reward Prediction Error (RPE), decoupling short-term interaction from long-term cognitive restructuring.
- Methodology Develops the LoCoMo-Noise benchmark with systematic 75% noise injection (Filler: 40%, Status: 30%, Tangent: 30%) to simulate real-world conversational dynamics and evaluate memory robustness.
- Methodology Implements zero-cost retrieval augmentation through hybrid BM25 search with Reciprocal Rank Fusion and an O(1) Shadow Buffer fallback mechanism to prevent adversarial hallucinations.
主要结论
- D-MEM reduces API token consumption by 80% (from 1,648K to 319K tokens) while maintaining or improving accuracy on complex reasoning tasks under extreme noise conditions (ρ=0.75).
- The architecture achieves superior multi-hop reasoning performance (42.7% F1 vs. A-MEM's 27.0%, a +15.7 point gap) by preserving cleaner relational memory structures through selective cognitive restructuring.
- The Critic Router successfully gates 80% of computational resources while maintaining overall F1 score of 37.4% on standard benchmarks, demonstrating the effectiveness of the bio-inspired RPE mechanism.
摘要: The integration of structured, long-term memory is critical for the development of autonomous Large Language Model (LLM) agents. Recent advancements, such as the Agentic Memory (A-MEM) framework, have achieved significant progress by dynamically constructing and evolving knowledge graphs. However, existing architectures inherently operate as synchronous, "append-and-evolve-all" systems. Processing every user utterance through a computationally expensive O(N²) memory evolution pipeline introduces severe write-latency, unbounded API token costs, and catastrophic context window pollution caused by conversational noise. To address this scalability bottleneck, we introduce D-MEM (Dopamine-Gated Agentic Memory), a biologically inspired architecture that decouples short-term interaction from long-term cognitive restructuring. Drawing inspiration from the Dopamine-driven Reward Prediction Error (RPE) gating mechanism in the mammalian Ventral Tegmental Area (VTA), D-MEM implements a highly efficient Fast/Slow routing system. We introduce a lightweight Critic Router that continuously evaluates the Information Entropy (Surprise) and Long-term Utility of incoming stimuli. Routine inputs with low RPE are either bypassed entirely or cached in an O(1) fast-access buffer, preserving computational resources. Conversely, inputs generating a high RPE—such as factual contradictions or paradigm-shifting preference changes—trigger a "dopamine release" that activates the slow, O(N) deep memory evolution pipeline, actively reshaping the agent's global knowledge graph. To enable rigorous evaluation under realistic conditions, we further introduce the LoCoMo-Noise benchmark, which systematically injects controlled conversational noise into long-term dialogue sessions to simulate real-world interaction dynamics. Extensive evaluations demonstrate that D-MEM reduces API token consumption by over 80% and eliminates O(N²) write-latency bottlenecks, all while strictly outperforming synchronous baselines in complex multi-hop reasoning and adversarial resilience. By selectively gating cognitive restructuring and leveraging zero-cost retrieval augmentations, D-MEM provides a highly scalable and cost-efficient foundation for lifelong agentic memory. To support reproducibility, we open-source our implementation at https://github.com/london-and-tequila/dmem.