Paper List
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Evolutionarily Stable Stackelberg Equilibrium
通过要求追随者策略对突变入侵具有鲁棒性,弥合了斯塔克尔伯格领导力模型与演化稳定性之间的鸿沟。
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Recovering Sparse Neural Connectivity from Partial Measurements: A Covariance-Based Approach with Granger-Causality Refinement
通过跨多个实验会话累积协方差统计,实现从部分记录到完整神经连接性的重建。
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Atomic Trajectory Modeling with State Space Models for Biomolecular Dynamics
ATMOS通过提供一个基于SSM的高效框架,用于生物分子的原子级轨迹生成,弥合了计算昂贵的MD模拟与时间受限的深度生成模型之间的差距。
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Slow evolution towards generalism in a model of variable dietary range
通过证明是种群统计噪声(而非确定性动力学)驱动了模式形成和泛化食性的演化,解决了间接竞争下物种形成的悖论。
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Grounded Multimodal Retrieval-Augmented Drafting of Radiology Impressions Using Case-Based Similarity Search
通过将印象草稿基于检索到的历史病例,并采用明确引用和基于置信度的拒绝机制,解决放射学报告生成中的幻觉问题。
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Unified Policy–Value Decomposition for Rapid Adaptation
通过双线性分解在策略和价值函数之间共享低维目标嵌入,实现对新颖任务的零样本适应。
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Mathematical Modeling of Cancer–Bacterial Therapy: Analysis and Numerical Simulation via Physics-Informed Neural Networks
提供了一个严格的、无网格的PINN框架,用于模拟和分析细菌癌症疗法中复杂的、空间异质的相互作用。
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Sample-Efficient Adaptation of Drug-Response Models to Patient Tumors under Strong Biological Domain Shift
通过从无标记分子谱中学习可迁移表征,利用最少的临床数据实现患者药物反应的有效预测。
Formation of Artificial Neural Assemblies by Biologically Plausible Inhibition Mechanisms
Neuroscience Graduate Program, Federal University of Rio Grande do Sul, Brazil | Department of Computer Science, University of Exeter, UK | Department of Computer Science, University of Sheffield, UK | Physics Department, Federal University of Rio Grande do Sul, Brazil
30秒速读
IN SHORT: This work addresses the core limitation of the Assembly Calculus model—its fixed-size, biologically implausible k-WTA selection process—by introducing a dynamic, gamma-oscillation-inspired E%-WTA mechanism and feedforward inhibition, enabling more realistic, self-determined assembly formation and superior retrieval.
核心创新
- Methodology Proposes the E%-Winners-Take-All (E%-WTA) selection mechanism, inspired by gamma oscillation dynamics, which allows a variable number of neurons to fire based on input strength, replacing the fixed-k selection of the original model.
- Methodology Integrates a biologically plausible feedforward inhibition mechanism based on the cortical excitatory-inhibitory neuron ratio (e.g., pi=0.2), enhancing network stability and assembly formation.
- Biology Defines a more rigorous, multi-condition criterion for assembly formation (stationary pattern, synchronization, higher synaptic density), moving beyond the original model's simpler 'no new winners' rule.
主要结论
- The E%-WTA model with feedforward inhibition (ωinh = -0.2, β ≤ 0.01) successfully forms neural assemblies where size is dynamically determined by network activity, not preset, addressing a key biological limitation.
- The new model achieves a superior assembly recovery rate (evocation accuracy) compared to the original AC model, demonstrating enhanced functional stability and memory retrieval capability.
- The introduced formation conditions (stationary pattern, synchronization, higher synaptic density) converge reliably in simulations, providing a robust framework for defining and identifying stable neural assemblies.
摘要: As proposed by Hebb’s theory, neural assemblies are groups of excitatory neurons that fire synchronously and exhibit high synaptic density, representing external stimuli and supporting cognitive functions such as language and decision-making. Recently, a model called Assembly Calculus (AC) was proposed, enabling the formation of artificial neural assemblies through the kk-winners-take-all selection process and Hebbian learning. Although the model is capable of forming assemblies according to Hebb’s theory, the adopted selection process does not incorporate essential aspects of biological neural computation, as neural activity, which is often governed by statistical distributions consistent with power-law scaling. Given this limitation, the present work aimed to bring the model’s dynamics closer to that observed in real cortical networks. To achieve this, a new selection mechanism inspired by the dynamics of gamma oscillation cycles, called E%-winners-take-all, was implemented, combined with an inhibition process based on the ratio between excitatory and inhibitory neurons observed in various regions of the cerebral cortex. The results obtained from our model (called E%-WTA model) were compared with those of the original model, and the analyses demonstrated that the introduced modifications allowed the network’s own dynamics to determine the size of the formed assemblies. Furthermore, the recovery rate of these groups, through the evocation of the stimuli that generated them, became superior to that obtained in the original model.