Paper List
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Discovery of a Hematopoietic Manifold in scGPT Yields a Method for Extracting Performant Algorithms from Biological Foundation Model Internals
This work addresses the core challenge of extracting reusable, interpretable, and high-performance biological algorithms from the opaque internal repr...
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MS2MetGAN: Latent-space adversarial training for metabolite–spectrum matching in MS/MS database search
This paper addresses the critical bottleneck in metabolite identification: the generation of high-quality negative training samples that are structura...
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Toward Robust, Reproducible, and Widely Accessible Intracranial Language Brain-Computer Interfaces: A Comprehensive Review of Neural Mechanisms, Hardware, Algorithms, Evaluation, Clinical Pathways and Future Directions
This review addresses the core challenge of fragmented and heterogeneous evidence that hinders the clinical translation of intracranial language BCIs,...
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Less Is More in Chemotherapy of Breast Cancer
通过纳入细胞周期时滞和竞争项,解决了现有肿瘤-免疫模型的过度简化问题,以定量比较化疗方案。
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Fold-CP: A Context Parallelism Framework for Biomolecular Modeling
This paper addresses the critical bottleneck of GPU memory limitations that restrict AlphaFold 3-like models to processing only a few thousand residue...
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Open Biomedical Knowledge Graphs at Scale: Construction, Federation, and AI Agent Access with Samyama Graph Database
This paper addresses the core pain point of fragmented biomedical data by constructing and federating large-scale, open knowledge graphs to enable sea...
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Predictive Analytics for Foot Ulcers Using Time-Series Temperature and Pressure Data
This paper addresses the critical need for continuous, real-time monitoring of diabetic foot health by developing an unsupervised anomaly detection fr...
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Hypothesis-Based Particle Detection for Accurate Nanoparticle Counting and Digital Diagnostics
This paper addresses the core challenge of achieving accurate, interpretable, and training-free nanoparticle counting in digital diagnostic assays, wh...
Formation of Artificial Neural Assemblies by Biologically Plausible Inhibition Mechanisms
Neuroscience Graduate Program, Federal University of Rio Grande do Sul, Brazil | Department of Computer Science, University of Exeter, UK | Department of Computer Science, University of Sheffield, UK | Physics Department, Federal University of Rio Grande do Sul, Brazil
30秒速读
IN SHORT: This work addresses the core limitation of the Assembly Calculus model—its fixed-size, biologically implausible k-WTA selection process—by introducing a dynamic, gamma-oscillation-inspired E%-WTA mechanism and feedforward inhibition, enabling more realistic, self-determined assembly formation and superior retrieval.
核心创新
- Methodology Proposes the E%-Winners-Take-All (E%-WTA) selection mechanism, inspired by gamma oscillation dynamics, which allows a variable number of neurons to fire based on input strength, replacing the fixed-k selection of the original model.
- Methodology Integrates a biologically plausible feedforward inhibition mechanism based on the cortical excitatory-inhibitory neuron ratio (e.g., pi=0.2), enhancing network stability and assembly formation.
- Biology Defines a more rigorous, multi-condition criterion for assembly formation (stationary pattern, synchronization, higher synaptic density), moving beyond the original model's simpler 'no new winners' rule.
主要结论
- The E%-WTA model with feedforward inhibition (ωinh = -0.2, β ≤ 0.01) successfully forms neural assemblies where size is dynamically determined by network activity, not preset, addressing a key biological limitation.
- The new model achieves a superior assembly recovery rate (evocation accuracy) compared to the original AC model, demonstrating enhanced functional stability and memory retrieval capability.
- The introduced formation conditions (stationary pattern, synchronization, higher synaptic density) converge reliably in simulations, providing a robust framework for defining and identifying stable neural assemblies.
摘要: As proposed by Hebb’s theory, neural assemblies are groups of excitatory neurons that fire synchronously and exhibit high synaptic density, representing external stimuli and supporting cognitive functions such as language and decision-making. Recently, a model called Assembly Calculus (AC) was proposed, enabling the formation of artificial neural assemblies through the kk-winners-take-all selection process and Hebbian learning. Although the model is capable of forming assemblies according to Hebb’s theory, the adopted selection process does not incorporate essential aspects of biological neural computation, as neural activity, which is often governed by statistical distributions consistent with power-law scaling. Given this limitation, the present work aimed to bring the model’s dynamics closer to that observed in real cortical networks. To achieve this, a new selection mechanism inspired by the dynamics of gamma oscillation cycles, called E%-winners-take-all, was implemented, combined with an inhibition process based on the ratio between excitatory and inhibitory neurons observed in various regions of the cerebral cortex. The results obtained from our model (called E%-WTA model) were compared with those of the original model, and the analyses demonstrated that the introduced modifications allowed the network’s own dynamics to determine the size of the formed assemblies. Furthermore, the recovery rate of these groups, through the evocation of the stimuli that generated them, became superior to that obtained in the original model.