Paper List
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EnzyCLIP: A Cross-Attention Dual Encoder Framework with Contrastive Learning for Predicting Enzyme Kinetic Constants
This paper addresses the core challenge of jointly predicting enzyme kinetic parameters (Kcat and Km) by modeling dynamic enzyme-substrate interaction...
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Tissue stress measurements with Bayesian Inversion Stress Microscopy
This paper addresses the core challenge of measuring absolute, tissue-scale mechanical stress without making assumptions about tissue rheology, which ...
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DeepFRI Demystified: Interpretability vs. Accuracy in AI Protein Function Prediction
This study addresses the critical gap between high predictive accuracy and biological interpretability in DeepFRI, revealing that the model often prio...
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Hierarchical Molecular Language Models (HMLMs)
This paper addresses the core challenge of accurately modeling context-dependent signaling, pathway cross-talk, and temporal dynamics across multiple ...
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Stability analysis of action potential generation using Markov models of voltage‑gated sodium channel isoforms
This work addresses the challenge of systematically characterizing how the high-dimensional parameter space of Markov models for different sodium chan...
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Personalized optimization of pediatric HD-tDCS for dose consistency and target engagement
This paper addresses the critical limitation of one-size-fits-all HD-tDCS protocols in pediatric populations by developing a personalized optimization...
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Consistent Synthetic Sequences Unlock Structural Diversity in Fully Atomistic De Novo Protein Design
This paper addresses the core pain point of low sequence-structure alignment in existing synthetic datasets (e.g., AFDB), which severely limits the pe...
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Generative design and validation of therapeutic peptides for glioblastoma based on a potential target ATP5A
This paper addresses the critical bottleneck in therapeutic peptide design: how to efficiently optimize lead peptides with geometric constraints while...
Decoding Selective Auditory Attention to Musical Elements in Ecologically Valid Music Listening
Sony Computer Science Laboratories, Inc, Tokyo, Japan
The 30-Second View
IN SHORT: This paper addresses the core challenge of objectively quantifying listeners' selective attention to specific musical components (e.g., vocals, drums, bass) during naturalistic music listening, a task previously hindered by the lack of overt behavioral correlates and reliance on simplified, non-ecological stimuli.
Innovation (TL;DR)
- Methodology First study to decode auditory attention using real, studio-produced, polyphonic songs across diverse genres (pop, rock, jazz, electronic), moving beyond simplified instrument tracks or synthetic mixtures.
- Methodology Demonstrates the practical feasibility of using a lightweight, four-channel consumer-grade EEG device (Muse2) for reliable neural decoding in an ecologically valid music listening paradigm.
- Biology Provides empirical evidence that a frontal–temporal four-electrode montage can effectively support the decoding of selective musical attention, offering insights into the neural correlates of auditory focus.
Key conclusions
- The 'Model: all-0 ms' (trained on all trials without EEG-audio delay) achieved the highest global decoding accuracy, significantly outperforming models trained only on high-attention trials ('attn-0 ms', p=1.89e-25) or with a 200ms delay ('all-200 ms', p=2.31e-19).
- The model demonstrated robust generalization, achieving a mean global accuracy of 86.41% across subjects for unseen songs and maintaining performance (mean 84.54%) even when evaluated only on trials where participants self-reported high attention.
- Decoding performance was stable across the four musical component tasks (Vocal, Drum, Bass, Others) in the best model, with task-level accuracy exceeding 80% for all tasks in the all-data evaluation, though performance on the Bass task was comparatively lower (65%) in the high-attention evaluation.
Abstract: Art has long played a profound role in shaping human emotion, cognition, and behavior. While visual arts such as painting and architecture have been studied through eye-tracking, revealing distinct gaze patterns between experts and novices, analogous methods for auditory art forms remain underdeveloped. Music, despite being a pervasive component of modern life and culture, still lacks objective tools to quantify listeners’ attention and perceptual focus during natural listening experiences. To our knowledge, this is the first attempt to decode selective attention to musical elements using naturalistic, studio-produced songs and a lightweight consumer-grade EEG device with only four electrodes. By analyzing neural responses during real-world–like music listening, we test whether decoding is feasible under conditions that minimize participant burden and preserve the authenticity of the musical experience. Our contributions are fourfold: (i) decoding music attention in real studio-produced songs, (ii) demonstrating feasibility with a four-channel consumer EEG, (iii) providing insights for music attention decoding, and (iv) demonstrating improved model ability over prior work. Our findings suggest that musical attention can be decoded not only for novel songs but also across new subjects, showing performance improvements compared to existing approaches under our tested conditions. These findings show that consumer-grade devices can reliably capture signals, and that neural decoding in music could be feasible in real-world settings. This paves the way for applications in education, personalized music technologies, and therapeutic interventions.